Barry & Cisco Seek Kara’s Help in the Superhero Crossover Episode of “Supergirl” Episode ‘Medusa’

The CW network has released the synopsis for episode #208 of Supergirl, which you can check out below. The installment, titled “Medusa,” is officially described as follows:

A NIGHT OF CONFESSIONS; THE EPIC SUPERHERO CROSSOVER KICKS OFF TONIGHT — Eliza (guest star Helen Slater) comes to town to celebrate Thanksgiving with her daughters. Alex (Chyler Leigh) decides it’s time to come out to her mother; Kara (Melisa Benoist) is shocked when Eliza suggests Mon-El (Chris Wood) has feelings for her, and Winn (Jeremy Jordan) and James (Mehcad Brooks) consider telling Kara the truth about the Guardian. Meanwhile, CADMUS unleashes a virus that instantly kills any alien in the vicinity so Kara enlists an unexpected ally – Lena Luthor (Katie McGrath). The epic superhero crossover kicks off tonight when Barry Allen (guest star Grant Gustin) and Cisco Ramon (guest star Carlos Valdes) seek Kara’s help with an alien invasion on their Earth.

Supergirl “Medusa” was directed by Stefan Pleszczynski and written by Jessica Queller & Derek Simon. The episode airs Monday, November 28, at 8pm on The CW.